Denosy® contains S-adenosylmethionine (SAMe), a precursor to the potent antioxidant Glutathione that protects hepatic cells from toxins and death. It is recommended to improve hepatic glutathione levels in patients to help maintain and protect liver function^3,4. Denosyl® may also be used in other areas of tissue oxidative injury caused by certain toxins or drugs which are related to reduced glutathione concentrations.⁴ Denosy®, however, goes beyond increasing glutathione levels and has been shown to protect liver cells from cell death and may be useful in cell regeneration.^1,5

• 犬と猫の肝臓の解毒作用をサポートします
• 特定の薬剤によって引き起こされる組織の酸化ストレスおよび血球の脆弱性に対しても作用し得ます
• 薬物療法によって引き起こされ得る肝臓への悪影響を防ぐことができます
• Very high safety profile ^1,3,4
• Also, supports healthy brain function in senior dogs

肝臓

The liver is one of the largest organs in the body and performs many life-essential functions. It produces a vast number of hormones, enzymes, proteins, and other substances important for your pet’s life and well-being. It also detoxifies and removes waste products in the bloodstream by changing them to a form that can be eliminated. This filtering of waste products is important because toxins can damage the membranes of cells in the liver and other organs. The most important liver “detoxifier” is glutathione, a potent antioxidant and the liver’s first line of defense.

抗酸化療法

Both dogs and cats make glutathione from S-adenosylmethionine (SAMe). SAMe is formed naturally by the liver from the amino acid methionine, found in your pet’s diet. When the liver is compromised, production of SAMe decreases resulting in less glutathione.1 This further compromises liver function. A study of dogs and cats with various liver function problems reported that many had low liver glutathione levels.²

成分

有効成分のS-アデノシルメチオニン(SAMe)を含む腸溶錠です。

使用場面

PAW Denosyl® is used as adjunctive treatment for liver diseases or dysfunction, such as the following:

• 慢性肝炎
• 肝リピドーシス
• 肝胆管炎
• アセトアミノフェン中毒
• Corticosteroid use (Note: does not prevent corticosteroid-induced hepatic vacuolar change)
• その他急性あるいは慢性の肝疾患(肝毒性、肝腫瘍を含む)

投与量と使用方法

Absorption of Denosyl® is decreased when it is given with a meal. For optimal absorption, administer Denosyl® at least one hour before feeding your pet. For owners who find it difficult to administer tablets to their pets, Denosyl®tablet(s) may be disguised in a small bite of moist food. It is not necessary to withhold water from your pet when giving Denosyl®
In cats, tablets or capsules can “stick” in the throat instead of passing into the stomach. Therefore, cat owners should gently administer a small amount of water (ask your veterinarian for details) immediately following tablet administration to aid swallowing.
 
Denosyl® tablets should not be broken as the enteric coating of the Denosyl® tablet protects the active ingredient from destruction while in the stomach.
 
いつでもペットの状態に応じて錠剤の数を微調整することができます。用量を増減する場合、調整は1錠単位で行う必要があります。
 
長期にわたって1日あるいは3日おきに投与するケースが多いです。

参考文献

1. Center SA. Proceedings of the 18th ACVIM, Seattle, WA, 2000; 550-552.
2. Center SA. Proceedings of TNAVC, Orlando, FL 2001; 218-219.
3. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66(2):330-341.
4. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
5. Webster CRL, Boria P, Usechak P, Anwer MS. Vet Therapeutics 2002;3(4):474-484.
6. Center SA, Warner KL, Erb HN. Am J Vet Res 2002;63(8):1187-1197.